FORMULATION AND EVALUATION OF ANTIMICROBIAL HERBAL CREAMS FROM AQUEOUS EXTRACT OF MORINGA OLEIFERA LAM SEEDS

Authors

  • S. E. Okafo
  • C. O. Akpo
  • C. C. Okafor

Keywords:

Moringa oleifera seeds, aqueous extract, antimicrobial, creams

Abstract

This study was carried out to evaluate the antimicrobial activity of ethanolic extract, aqueous extract and topical creams from Moringa oleifera seeds against some bacteria and fungi. M. oleifera seeds were dried, powdered and macerated for 24 and 48 h in water and ethanol respectively. The filtrates were concentrated and stored properly. Antimicrobial sensitivity tests were conducted on the aqueous and ethanolic extracts using standard agar diffusion method. The minimum inhibitory concentrations of both extracts were determined against various test organisms. Creams were formulated using the aqueous extract. They were evaluated based on organoleptic properties, pH, viscosity and antimicrobial activities. The ethanolic extract was inactive against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans. The aqueous extract was active against S. aureus, C. albicans, Trichophyton spp, Aspergillus flavus but inactive against E. coli, P. aeruginosa, Microsporium spp, and Rhizopus spp. The MIC for sensitive organisms was achieved with 2.5 to 5%w/v concentration of the aqueous extract. Positive results were also obtained with the cream formulations. The pH of the cream formulations ranged from 4.17 to 4.33.The study showed that the antimicrobial property of the aqueous extract was retained by the cream formulations and both the aqueous extract and cream formulation could respectively be used to treat skin diseases caused by S. aureus, C. albicans, Trichophyton spp and A. flavus

Downloads

Published

2022-06-23

How to Cite

Okafo, S. E. ., Akpo, C. O., & Okafor, C. C. (2022). FORMULATION AND EVALUATION OF ANTIMICROBIAL HERBAL CREAMS FROM AQUEOUS EXTRACT OF MORINGA OLEIFERA LAM SEEDS. NIGERIAN JOURNAL OF SCIENCE AND ENVIRONMENT, 18(1). Retrieved from https://delsunjse.com/index.php/njse/article/view/66