EVALUATION OF MICROCRYSTALLINE CELLULOSE DERIVED FROM CASSAVA PEEL AS DISINTEGRANT IN PARACETAMOL TABLET FORMULATION
Keywords:Cassava peel, disintegrant property, microcrystalline cellulose, paracetamol
Agricultural wastes can be harnessed as raw materials for other products thereby creating wealth, preventing environmental degradation and ultimately ensuring the achievement of the sustainable development goals. The purpose of this study is to investigate the disintegrant property of microcrystalline cellulose extracted from cassava peel in paracetamol tablet formulation. Cellulose was extracted from cassava peel using the Sodium hydroxide method and subsequently hydrolysed to obtain cassava peel microcrystalline cellulose (CP-MCC). The CP-MCC was used as disintegrant in the formulation of paracetamol tablet. The formulated tablets were evaluated using the following parameters: uniformity of weight, hardness, friability, disintegration time and dissolution rate test. Batches CP1, CP2, and CP3 failed the weight uniformity test while batch CP4 complied with the test
having a deviation of less than 5% (3.99%). All batches had fairly good tablet hardness with batch CP1 having the lowest hardness of 4.3 kg. Batches CP1 and CP2 complied with the official test for friability with values of 0.85% and 0.58% respectively, while CP3 and CP4 did not comply having values of 1.10 and 1.20% respectively. Tablets from all batches disintegrated within 15 min with batch CP2 showing the best disintegration time of 5.29 min; however batch CP2 released only about 55% of the paracetamol in 45 min while batch CP3 released over 80 % of paracetamol in 45 minutes. It can be concluded that CP-MCC obtained from cassava peel could be used as disintegrant for the formulation of paracetamol tablets.